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Depression - understanding risk factors, symptoms and therapies: A conversation with Dr Joni Coleman
This is the second episode in a collaborative series between I’m Fine podcast and the Medical Research Foundation.
In today’s conversation, Jean Campbell speaks to Dr Joni Coleman, Senior Lecturer in Statistical Genetics at the Institute of Psychiatry, Psychology & Neuroscience, King’s College London, about depression and how factors such as genetics, environment and trauma shape mental health.
*Please note that Joni is not a clinician so his comments shouldn’t be interpreted as clinical opinion.
The Medical Research Foundation is at the forefront of tackling often-overlooked health challenges, from chronic pain to areas of medical health that don’t receive the attention they deserve.
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Resources and research, shared by Dr Joni Coleman
Overall [Primer on major depressive disorder]
Overall [Lancet-WPA Commission]
0:00-1:35 [Symptoms and differing experiences]
3:45 [Depression as a risk factor for suicide]
4:00-4:37 [Minimisation and maximisation]
4:54-5:44 [Typical duration of depressive episodes]
6:00-6:10 [4-5% of people experiencing depression]
6:20 [Barriers to treatment seeking]
6:57-7:30 [Rate of depression is increasing]
7:31 [Global variation in depression]
8:00 [Neurasthenia as an alternative to depression]: https://pmc.ncbi.nlm.nih.gov/articles... https://europepmc.org/article/med/113...
8:56 [Different forms of depression]
9:50 [Postnatal depression]
11:03 [Factors affecting suicide]
12:52 [Neuroimaging features related to suicide]
14:17 [Neuroimaging features related to depression]
15:09 [Sex differences in response to stress]
16:15 [Where does depression come from?]
17:32 [Genetic counselling for psychiatric disorders]
18:27 [37 different factors influencing depression]
19:13 [Genetics accounts for 30-40% of variance between people]
19:33 [Height and weight, genetics accounts for 60-80% of variance]: https://pmc.ncbi.nlm.nih.gov/articles... https://www.sciencedirect.com/science...
20:24 [Different mechanisms for trauma]
21:16 [Resilience]
23:26 [Cognitive behavioural therapy]
26:52 [Nurturing environments can be protective against high genetic risk for depression]
27:58 [Role of environmental factors in depression]: https://onlinelibrary.wiley.com/doi/f..., https://psychiatryonline.org/doi/full...
29:15 [Role of genetics and exercise in depression]
30:14 [Relatively few studies targeting lifestyle interventions]
31:25 [Mindfulness as a third-wave cognitive behavioural therapy]
31:38 [Mindfulness as a therapy]
32:30 [UK Biobank mental health questionnaires]: https://www.ukbiobank.ac.uk/enable-yo..., https://pubmed.ncbi.nlm.nih.gov/32026...
33:02 [Endorsement of mindfulness and other therapies]
33:47 [Social media impact on eating disorders]
35:56 [NICE guidelines for the treatment of depression]: https://www.nice.org.uk/guidance/ng222, https://www.nice.org.uk/guidance/ng134
37:27 [Electroconvulsive therapy (ECT)]
This video discusses suicide and/or self-harm, so please view with care. If you are feeling suicidal, know that help is available. Contact the Samaritans on 116 123 if you need emotional support. If you feel you are in immediate danger to yourself, call 999.